ENDOKRINOLOGI Sudarno, dr., M.Kes. Departemen Biokimia

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BIOKIMIA ENDOKRIN
dr.Syazili Mustofa
.
Departemen Biokimia Kedokteran
UNIVERSITAS LAMPUNG
Kenapa penting??
Dasar untuk mempelajari penyakit gangguan
endokrin.
Gangguan endokrin yang sering ditemui adalah:
 Diabetes melitus
 Hipertiroidisme
Mechanism of Hormone Action
• Hormones are carried by the blood, yet they affect only
certain cells. The specific cells that respond to a given
hormone have receptor sites for that hormone.
• Receptor sites may be located on the surface of the cell
membrane or in the interior of the cell.
SISTEM HORMON
Hormon = membangkitkan aktivitas
Hormon oleh jar. → sistem sirkulasi → jar. Lain
 Parakrin → organ sama jaringan berbeda
 Autokrin →organ dan jaringan yg sama

Hormon dapat ditargetkan pada lebih dari satu
jaringan .
Kelenjar target:


± 200 tipe sel tubuh
± 50 hormon yang sudah dikenal
Reseptor Hormon
Ada dua macam reseptor hormon:
1.Reseptor yang mengikat hormon di luar sel.
Hormon polipeptida, protein, dan
katekolamin terikat reseptor pada
membran plasma → menyalur fungsi ke
intrasel melalui aktivitas enzim adenilil
siklase  cAMP dan
fosfolipase C  Ca++
2.Reseptor yang mengikat hormon intraselluler
Hormon Steroid dan Tiroid,  Transkripsi
Mechanism of Hormone Action
• Protein hormones, in general, are water soluble and are
unable to diffuse through the cell membrane and react with
receptor sites on the surface of the cell.
• Steroids are fat soluble and can diffuse through the cell
membrane and react with receptors inside the cell.
Mechanism of Hormone Action
Mechanism of Hormone Action
 HORMON RESEPTOR MEMBRAN;
- ACTH
- ADH
- FSH
- hcG
- LIPOPROTEIN = LPH
- LUTEINISASI = LH
- TSH
- PARATIROID (PTH)
- GLUKAGON
- INSULIN
- ADRENALIN DAN NOR ADRENALIN
Mechanism of steroid Hormone Action
Mechanism of steroid Hormone Action
 HORMON RESEPTOR INTRASEL:
-
ESTROGEN
GLUKOKORTIKOID
MINERALOKORTIKOID
PROGESTIN
KALSITRIOL
ANDROGEN
TIROID = T4;T3
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