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44
Lampiran 1 : Hasil sekuensing dalam bentuk elektroforegram
A. Individu umur 10 tahun
B. Individu umur 20 tahun
45
C. Individu umur 30 tahun
46
D. Individu umur 40 tahun
47
48
49
E. Individu umur 80 tahun
50
51
52
Lampiran 2 : Urutan nukleotida 12 sampel dari lima individu yang berbeda umur
Sampel
Darah
10
Rambut
20
Darah
Rambut
30
Darah
Epitel
Rambut
Posisi
Urutan nukleotida
nukleotida
53
Darah
Epitel
40
Rambut
Darah
80
Rambut
54
Lampiran 3:
Elektroforegram sampel yang menunjukkan mutasi pada 12 sampel
A. Individu umur 10 tahun
B. Individu umur 20 tahun
55
C. Individu umur 30 tahun
56
D. Individu umur 40 tahun
57
58
59
E. Individu umur 80 tahun
60
61
62
Lampiran 4 :
Fungsi lokasi pada DNA mitokondria manusia
Posisi (nt)
1
57-372
110-441
213-235
233-260
276-303
299-31
317-321
346-363
371-379
384-391
392-445
418-445
52-550
545-567
577-647
645-645
648-1601
1602-1670
1671-3229
3206-3229
3229-3256
3230-3304
3305-3306
3307-4262
4263-4331
4329-400
4401-4401
4402-4469
4470-5511
5512-576
5577-5576
5587-5655
5656-5656
5657-5729
5721-5798
5761-5826
5826-5891
5892-5903
5904-7445
7445-7516
7517-7517
Singkatan
2
HVSII
OH
CSB1
CSB2
CSB3
PL
PH1
F
PH2
12s
V
16s
L
ND1
I
Q
M
ND2
W
A
N
OL
C
Y
COI
S
Deskripsi
3
Hypervariable segment 2
H-strand origin
Conserved sequence block I
mtTF1 binding site
mtTF1 binding site
Conserved sequence block II
Replication primer
Conserved sequence block III
Mt4 H-strand control element
Mt3 H-strand control element
L-strand promoter
mtTF1 binding site
mtTF1 binding site
Major-H-strand promoter
tRNA Phenylalanine
Minor-H-strand promoter
12s rRNA
tRNA Valine
16s rRNA
5S-like sequence
Transkription terminator
tRNA Leucine 1
Non-coding nucleotides
NADH dehydogenase 1
tRNA Isoleucine
tRNA Glutamine
Non-coding nucleotides
tRNA Methionine
NADH dehydogenase 2
Trna Trytophan
Non-coding nucleotides
tRNA Alanine
Non-coding nucleotides
tRNA Asparagine
L-strand origin
tRNA Cysteine
tRNA Tyrosine
Non-coding nucleotides
Cytochrome c oxidase I
tRNA Serine
Non-coding nucleotides
63
1
2
3
tRNA Aspartic acid
Cytochrome c oxidase II
Non-coding nucleotides
tRNA Lysine
Non-coding nucleotides
ATP synthase 8
ATP synthase 6
Cytochrome c oxidase III
tRNA Glycine
NADH dehydrogenase 3
tRNA Arginine
NADH dehydrogenase 4L
NADH dehydrogenase 4
tRNA histidine
tRNA Serine 2
tRNA Lysine 2
NADH dehydrogenase 5
NADH dehydrogenase 6
tRNA Glutamic acid
Non-coding nucleotides
Cytochrame b
tRNA Threonine
Membrane attachment site
Non-coding nucleotides
tRNA praline
Displacement loop(see note below)
Hypervaiable segment 1
7s DNA
Termination sequence
Control element
L-strand control element
7518-7585
D
7586-8269
COII
8270-8294
8295-8364
K
8365-8365
8366-8572
ATPase8
8527-9207
ATPase6
9207-9990
COII
9991-10058
G
10059-10404
ND3
10405-10469
R
10470-10766
ND4L
10760-12137
ND4
12138-12206
H
12207-12265
S
12266-12336
L
12337-14148
ND5
14149-14673
ND6
14674-14742
E
14743-14746
1474715887
CytB
15888-15953
T
15925-499
15954-15954
15955-16023
P
16024-576
D-Loop
16024-16383
HVSI
16106-191
7S
16175-16172
TAS
16194-16208
mt5
16499-16506
mt3
Sumber : MITOMAP (http://www.mitomap.org)
Catatan :
- “D-Loop” merujuk pada daerah yang tidak mengode ( non-coding region) antara
prolin and phenylalanin (np 16024-576)
- Posisi nukleotida (np) ditentukan berdasarkan urutan nukleotida DNA. Posisi
nukleotida (np) merujuk pada nomor nukleotida berdasarkan urutan CRS yang
digunakan sebagai standar
- Posisi promoter untai L-teridentifikasi pada nukleotida 407, 392-435.
- Posisi promoter untai H-teridentifikasi pada nukleotida 559-561
- Posisi replikasi untai L teridentifikasi pada nukleotida 5721-5781, 5761, 5799.