viii DAFTAR ISI HALAMAN JUDUL

DAFTAR ISI
HALAMAN JUDUL .............................................................................................. i
HALAMAN PENGESAHAN .............................................................................. iii
HALAMAN PERNYATAAN.............................................................................. iv
HALAMAN PERSEMBAHAN ............................................................................v
KATA PENGANTAR .......................................................................................... vi
DAFTAR ISI....................................................................................................... viii
DAFTAR GAMBAR ..............................................................................................x
DAFTAR TABEL ................................................................................................ xi
DAFTAR LAMPIRAN ....................................................................................... xii
INTISARI ........................................................................................................... xiv
BAB I. PENDAHULUAN ......................................................................................1
A. LATAR BELAKANG ..................................................................................1
B. RUMUSAN MASALAH ..............................................................................4
C. TUJUAN PENELITIAN ...............................................................................4
D. TINJAUAN PUSTAKA ...............................................................................5
1.
Jahe (Zingiber officinale Rosc.) ................................................................5
2.
Ekstraksi ....................................................................................................9
3.
Uji Toksikologi .......................................................................................13
4.
Teratogenesis ...........................................................................................13
5.
Uji Keteratogenikan ................................................................................15
6.
Siklus Estrus Tikus Betina ......................................................................18
7.
Embriologi ...............................................................................................22
8.
Biometrika Janin .....................................................................................24
E. KETERANGAN EMPIRIS ........................................................................25
BAB II. CARA PENELITIAN ............................................................................26
A. RANCANGAN PENELITIAN ...................................................................26
B. ALAT DAN BAHAN PENELITIAN .........................................................26
C. JALANNYA PENELITIAN .......................................................................28
D. METODE ANALISIS .................................................................................35
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E. SKEMA PENELITIAN ..............................................................................36
BAB III. HASIL DAN PEMBAHASAN ............................................................38
A. ANALISIS KUALITATIF FRAKSI ZAT PEDAS JAHE .........................38
B. BIOMETRIKA JANIN ...............................................................................41
1.
Bobot Plasenta .........................................................................................42
2.
Bobot dan Panjang Janin .........................................................................45
3.
Jumlah Janin Mati ...................................................................................48
4.
Jumlah Resorpsi ......................................................................................49
BAB IV. KESIMPULAN DAN SARAN ............................................................54
A. KESIMPULAN ...........................................................................................54
B. SARAN .......................................................................................................54
DAFTAR PUSTAKA ...........................................................................................56
LAMPIRAN. .........................................................................................................61
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DAFTAR GAMBAR
Gambar 1. Rimpang jahe (Zingiber officinale Rosc.) ..............................................6
Gambar 2. Struktur komponen non-volatil jahe ......................................................7
Gambar 3. Alat maserasi dengan pengaduk mekanik ............................................12
Gambar 4. Sel-sel epitel vagina daur estrus ...........................................................19
Gambar 5. Perkembangan embrio tikus .................................................................23
Gambar 6. Perkembangan embrio manusia ...........................................................24
Gambar 7. Skema preparasi sampel uji ..................................................................36
Gambar 8. Skema pelaksanaan penelitian..............................................................37
Gambar 9. Profil KLT fraksi zat pedas jahe ..........................................................40
Gambar 10. Hasil pengamatan plasenta .................................................................44
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DAFTAR TABEL
Tabel I.
Jenis pelarut dan jenis senyawa terlarut ............................................11
Tabel II.
Data kuantitatif pengamatan biometrika janin akibat pemejanan
fraksi zat pedas jahe (Zingiber officinale Rosc.)...............................42
Tabel III.
Data bobot plasenta berbagai perlakuan akibat efek pemejanan fraksi
zat pedas jahe (Zingiber officinale Rosc.).........................................43
Tabel IV.
Data bobot janin berbagai perlakuan akibat efek pemejanan fraksi zat
pedas jahe (Zingiber officinale Rosc.) ..............................................45
Tabel V.
Data panjang janin berbagai perlakuan akibat efek pemejanan fraksi
zat pedas jahe (Zingiber officinale Rosc.).........................................47
Tabel VI.
Data jumlah janin sebagai efek pemejanan fraksi zat pedas jahe
(Zingiber officinale Rosc.) ................................................................48
Tabel VII.
Data jumlah korpus luteum, tempat implantasi, resorpsi awal, dan
resorpsi akhir berbagai perlakuan akibat efek pemejanan fraksi zat
pedas jahe (Zingiber officinale Rosc.) ..............................................50
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DAFTAR LAMPIRAN
Lampiran 1.
Data rata-rata bobot plasenta masing-masing induk tiap kelompok
perlakuan ........................................................................................61
Lampiran 1a. Data bobot plasenta tiap janin pada masing-masing induk
kelompok kontrol (CMC-Na 0,5%). ..............................................62
Lampiran 1b. Data bobot plasenta tiap janin pada masing-masing induk
kelompok dosis I (35mg/kgBB). ....................................................63
Lampiran 1c. Data bobot plasenta tiap janin pada masing-masing induk
kelompok dosis II (70mg/kgBB). ..................................................64
Lampiran 1d. Data bobot plasenta tiap janin pada masing-masing induk
kelompok dosis III (140mg/kgBB). ...............................................65
Lampiran 2.
Data rata-rata bobot janin masing-masing induk tiap kelompok
perlakuan. .......................................................................................66
Lampiran 2a. Data bobot tiap janin pada masing-masing induk kelompok kontrol
(CMC-Na 0,5%) .............................................................................67
Lampiran 2b. Data bobot tiap janin pada masing-masing induk kelompok dosis I
(35mg/kgBB) .................................................................................68
Lampiran 2c. Data bobot tiap janin pada masing-masing induk kelompok dosis II
(70mg/kgBB) .................................................................................69
Lampiran 2d. Data bobot tiap janin pada masing-masing induk kelompok dosis
III (140mg/kgBB) ..........................................................................70
Lampiran 3.
Data rata-rata panjang janin masing-masing induk tiap kelompok
perlakuan ........................................................................................71
Lampiran 3a. Data pa
jang tiap janin pada masing-masing induk kelompok kontrol (CMC-Na 0,5%) ...72
Lampiran 3b. Data panjang tiap janin pada masing-masing induk kelompok dosis
I (35mg/kgBB) ...............................................................................73
Lampiran 3c. Data panjang tiap janin pada masing-masing induk kelompok dosis
II (70mg/kgBB) ..............................................................................74
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Lampiran 3d. Data panjang tiap janin pada masing-masing induk kelompok dosis
III (140mg/kgBB) ..........................................................................75
Lampiran 4.
Data jumlah janin, jumlah korpus luteum, jumlah tempat
implantasi, dan resorpsi tiap kelompok perlakuan. ........................76
Lampiran 5.
Analisis SPSS data bobot plasenta .................................................78
Lampiran 6.
Analisis SPSS data bobot janin ......................................................80
Lampiran 7.
Analisis SPSS data panjang janin ..................................................82
Lampiran 8.
Analisis SPSS data resorpsi akhir ..................................................84
Lampiran 9.
Pengamatan daur estrus ..................................................................86
Lampiran 10. Pengamatan pada induk dan janin ..................................................89
Lampiran 11. Surat identifikasi tanaman..............................................................90
Lampiran 12. Surat keterangan kelaikan etik .......................................................91
Lampiran 13. Surat keterangan selesai penelitian ................................................92
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