24 oktober 2005 exercise PENGARUH RANGSANG EXERCISE TERHADAP HOMEOSTASIS exercise nani cahyani sudarsono – dep. i faal FKUI 2005 metabolisme otot Nani Cahyani Sudarsono gerakan otot REVIEWER: DEWI IRAWATI & MINARMA SIAGIAN DEPARTEMEN I FAAL FKUI SISTEM DALAM TUBUH YANG TERLIBAT DALAM HOMEOSTASIS D U Silverthorn, Human Physiology An Integrated Approach Figure 6-21: Comparison of local and reflex control Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Reflex Control exercise exercise z Stimulus z Sensory receptor z Afferent path z Integration center z Efferent path z Effector- target cell/tissue z Response (feedback loop) Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 Control Pathways ATP Figure 6-22: Steps of a reflex pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 1 METABOLISME OTOT PANAS 24 oktober 2005 exercise exercise nani cahyani sudarsono – dep. i faal FKUI 2005 Sistem Kardiorespirasi nani cahyani sudarsono – dep. i faal FKUI 2005 METABOLISME OTOT ATP METABOLISME OTOT ATP Bagaimana pengaturannya? Otot Gambar: D U Silverthorn, Human Physiology An Integrated Approach exercise PERUBAHAN NEURONEURO-HORMONAL ↓ insulin ↑ glukagon ↑ simpatis nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 HOMEOSTASIS ENERGI ↑ambilan & penggunaan glukosa di OTOT exercise PENGATURAN PERNAPASAN nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 PERUBAHAN NEURONEURO-HORMONAL ↓ insulin ↑ glukagon ↑ simpatis ↑ambilan & penggunaan glukosa di OTOT pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 2 24 oktober 2005 pengaturan pernapasan nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 pengaturan pernapasan Mempertahankan PO2 & PCO2 yang adekuat frekuensi & kedalaman napas Gambar: http://www.biology.eku.edu/RITCHISO/301notes6.htm PERUBAHAN VENTILASI hubungannya dengan PO2, PCO2 & pH Gambar: Marieb – A.D.A.M.S Interactive Physiology: Respiratory System exercise - peningkatan frekuensi & kedalaman pernapasan PUSAT PERNAPASAN SARAF PENGATURAN KERJA SISTEM KARDIOVASKULER METABOLISME OTOT ↑ HORMON SARAF GERAKAN OTOT PENINGKATAN KERJA OTOT PERNAPASAN NAPAS LEBIH CEPAT, LEBIH DALAM umpan balik nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 O2 ↓ CO2 ↑ um ke dpan epa n DARAH O2 ↑ CO2 ↓ DARAH SARAF “NIAT” INFORMASI DISAMPAIKAN MELALUI EXERCISE GAMBAR: http://web.ukonline.co.uk/webwise/spinneret/humans/inhexh.htm nani cahyani sudarsono – dep. i faal FKUI 2005 exercise Modulation of Contraction Mempertahankan perfusi jaringan yang adekuat TEKANAN DARAH Figure 14-12: Modulation of cardiac contraction by catecholamines Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 3 24 oktober 2005 Cardiovascular Response to Exercise Cardiovascular Response to Exercise Figure 25-7: Distribution of cardiac output at rest and during exercise Figure 25-7: Distribution of cardiac output at rest and during exercise Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings exercise nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 Apa dampak peningkatan aliran darah ke otot? click here ATP METABOLISME OTOT PANAS HOMEOSTASIS SUHU TUBUH METABOLISME OTOT BAGAIMANA pengaturannya? nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 exercise PANAS pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 4 24 oktober 2005 exercise nani cahyani sudarsono – dep. i faal FKUI 2005 METABOLISME OTOT PANAS Rhoades & Pflanzer, Human Physiology Gambar: Marieb E, Human Anatomy & Physiology exercise exercise nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 berkeringat HAUS BAGAIMANA mekanismenya? HAUS ↑ ADH release from Posterior Pituitary Cardiovascular Stretch Receptors ↑ Plasma ADH Osmoreseptor nani cahyani sudarsono – dep. i faal FKUI 2005 Dehydration ↓ Extracellular fluid volume ↑ Collecting Duct Water Permeability ↑ Plasma Osmolality Normal Fluid Volume Response to dehydration ↑ Water intake ↓ Water Excretion pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 5 Thirst ↑ Water Reabsorption Courtesy of Dewi Irawati – Dep of Physiology FMUI PENGATURAN IMBANGAN CAIRAN & ELEKTROLIT 24 oktober 2005 imbangan asam basa PENGATURAN IMBANGAN ASAM - BASA nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 pH tubuh optimal: 7.4 (6.9 - 7.7) produksi H+ ↑ pada exercise (pH↓) ventilasi ↑ cairan ekstrasel: ekstrasel: plasma & sel darah merah respons pernapasan respons ginjal END NOTE nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 END NOTE Pada seorang yang melakukan exercise, dapatkan Saudara menjelaskan mekanisme kerja berbagai sistem yang terlibat dalam homeostasis tubuh? Pada seorang yang melakukan exercise, dapatkan Saudara menjelaskan mekanisme kerja berbagai sistem yang terlibat dalam homeostasis tubuh? exercise sebagai rangsang: rangsang: exercise: z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis dampak terhadap homeostasis? sistemsistem-organ yang terlibat? terlibat? energi cairan suhu tubuh asam-basa elektrolit nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 ekskresi H+ sistem buffer energi cairan suhu tubuh asam-basa elektrolit pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 6 24 oktober 2005 exercise: sistem kontrol z Homeostasis z Homeostasis z Homeostasis z Homeostasis z Homeostasis energi cairan suhu tubuh asam-basa elektrolit nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 sistem kontrol yang berperan? berperan? z Cepat? Lambat? z Saraf? Endokrin? z Komunikasi antar sel? z Mekanisme? {Feedback (umpan balik) {Feedforward (umpan ke depan) manfaat melakukan exercise manfaat melakukan Hippocrates (460-370 SM) nani cahyani sudarsono – dep. i faal FKUI 2005 nani cahyani sudarsono – dep. i faal FKUI 2005 exercise if we could give every individual the right amount of nourishment and exercise, not too little and not too much, we would have found the safest way to health nani cahyani sudarsono – dep. i faal FKUI 2005 manfaat melakukan exercise Move for health Raga aktif untuk sehat pengaruh exercise terhadap homeostasis nani cahyani sudarsono - Departemen I FAAL FKUI 2005 7