ABSTRAK PENGARUH KUANTITAS TROMBOSIT DAN

xi
ABSTRAK
PENGARUH KUANTITAS TROMBOSIT DAN KOAGULASI DARAH
TERHADAP PROGRESIVITAS GLAUKOMA NORMOTENSI
Puji Lestari, Retno Ekantini, Hartono
Bagian Ilmu Kesehatan Mata RSUP Dr. Sardjito
Universitas Gadjah Mada Yogyakarta
Penelitian kasus kontrol pengaruh kuantitas trombosit dan koagulasi darah
terhadap progresivitas glaukoma normotensi untuk menentukan kontribusi koagulasi
darah sebagai faktor risiko progresivitas glaukoma normotensi. Subyek penelitian
dibagi menjadi kelompok glaukoma normotensi stabil sebagai kontrol dan kelompok
glaukoma normotensi progresif sebagai kasus, masing-masing 23 orang dengan
keterwakilan gender dengan usia 14-40 tahun. Pada kedua kelompok dilakukan
pemeriksaan angka trombosit, clotting time, bleeding time, prothrombin time,
activated partial thromboplastin time, dan GDS. Data pemeriksaan dianalisis dengan
analisis bivariat dan multivariat. Angka trombosit kelompok kasus tidak berbeda
dengan kelompok kontrol (OR 1,44; 95%CI 0,43-4,75; p=0,545). Nilai clotting time
kelompok kasus tidak berbeda bermakna dengan kelompok kontrol (OR 1,846;
95%CI 0,521-6,47; p=0,343). Nilai bleeding time kelompok kasus berbeda bermakna
dengan kelompok kontrol pada analisa bivariat (OR 9,800; 95%CI 1,089-88,229;
p=0,042). Nilai prothrombin time kelompok kasus tidak berbeda bermakna dengan
kelompok kontrol (OR 3,062; 95%CI 0,897-10,462; p=0,074). Nilai APTT kelompok
kasus tidak berbeda bermakna dengan kelompok kontrol (OR 1,524; 95%CI 0,4245,473; p=0,518).
Kata kunci: trombosit, koagulasi, progresivitas glaukoma normotensi
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ABSTRACT
THE INFLUENCED OF PLATELET COUNT AND BLOOD COAGULATION TO
PROGRESSIVENESS OF NORMAL TENSION GLAUCOMA
Puji Lestari, Retno Ekantini, Hartono
Ophthalmology Department of RSUP Dr. Sardjito
Universitas Gadjah Mada Yogyakarta
A case-control study of the influenced of platelet count and blood coagulation
to progressiveness of normal tension glaucoma to determine the contribution of
platelet count and blood coagulation as risk factor to progressiveness of normal
tension glaucoma. The subjects were divided into group of stabile normal tension
glaucoma and progressive normal tension glaucoma, each 23 patients with gender
representation at the age 14-40 years old. Platelet count, clotting time, bleeding time,
prothrombin time, activated partial thromboplastin time, dan random blood sugar
every patient were measured. The collected data were analyzed by bivariate and
multivariate analysis. Platelet count of case group was not significantly different from
the control group (OR 1,44; 95%CI 0,43-4,75; p=0,545). Clotting time of case group
was also not significantly different from the control group (OR 1,846; 95%CI 0,5216,47; p=0,343). Bleeding time of case group significantly different from the control
group with bivariate analysis (OR 9,800; 95%CI 1,089-88,229; p=0,042).
Prothrombin time of case group was not significantly different from the control group
(OR 3,062; 95%CI 0,897-10,462; p=0,074). APTT of case group was not
significantly different from the control group (OR 1,524; 95%CI 0,424-5,473;
p=0,518).
Key words: platelet, coagulation, progressiveness normal tension glaucoma