PENGARUH VITAMIN C TERHADAP KADAR MDA PLASMA dan

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PENGARUH VITAMIN C TERHADAP KADAR MDA PLASMA dan
LAMA RAWAT INAP PENDERITA PPOK EKSASEBASI AKUT
TESIS
Untuk memenuhi sebagian persyaratan mencapai Derajat Magister Kesehatan
Program Studi Magister Kedokteran Keluarga
Minat Utama Biomedik
Oleh
Fadlia Yulistiana
S501102019
PASCASARJANA
UNIVERSITAS SEBELAS MARET
SURAKARTA
2016
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Fadlia Yulistiana. 2016. Pengaruh Vitamin C terhadap Kadar MDA Plasma dan
Lama Rawat Inap Penderita PPOK Eksaserbasi Akut. TESIS. Supervisor I: Prof.
Dr. Suradi, dr., Sp.P(K),MARS, II: Dr. Reviono, dr., Sp.P(K). Program Studi Magister
Kedokteran KeluargaMinat Utama Biomedik Pasca Sarjana Universitas Sebelas Maret.
ABSTRAK
PPOK merupakan penyakit paru ditandai dengan hambatan aliran udara yang
bersifat kronik, progresif, dan tidak sepenuhnya reversible akibat inhalasi gas atau
partikel berbahaya sehingga terjadi inflamasi kronis saluran napas. Eksaserbasi dan
faktor komorbid berpengaruh terhadap derajad berat penyakit. Peningkatan inflamasi
saluran napas dan paru saat eksaserbasi menyebabkan peningkatan kadar MDA plasma
sehingga menyebabkan sebagian besar pasien butuh perawatan di RS. Vitamin C adalah
antioksidan vitamin yang memiliki efek antiinflamasi dan antioksidan sehingga dapat
ditambahkan pada PPOK eksaserbasi.
Metode penelitian menggunakan uji klinis eksperimental dengan pretest and
post-test design. Tujuannya adalah untuk mengetahui pengaruh vitamin C terhadap
kadar MDA plasma dan lama rawat inap penderita PPOK eksaserbasi. Digunakan 33
subjek penderita PPOK eksaserbasi akut yang dirawat di RSUD Soehadi Pridjonegoro
Sragen bulan Oktober-November 2015. Sampel diambil secara consecutive sampling.
Subjek dibagi dua kelompok, kelompok perlakuan (n=16) mendapatkan terapi tambahan
vitamin C 1x1000 mg/hari dan kelompok kontrol (n=17) mendapat terapi tambahan
NaCl 0,9% 5mL selama perawatan. Kadar MDA plasma diukur saat masuk dan saat
kriteria pemulangan terpenuhi. Lama rawat inap dihitung berdasarkan jumlah hari
perawatan di RS.
Tidak terdapat perbedaan bermakna secara statistik(nilai p=0,43) terhadap
penurunan kadar MDA plasma kelompok vitamin C (-0,86±5,59 µmol/L) dan kontrol (2,81±4,31). Tidak terdapat perbedaan bermakna secara statistik (p=0,27) terhadap lama
rawat inap antara kelompok vitamin C (4,88±2,13 hari) dan kontrol (5,88+2,64 hari).
Terapi tambahan vitamin C 1x1000 mg/ hari pada terapi standar PPOK
eksaserbasi akut pada subjek penelitian ini dapat menurunkan kadar MDA plasma dan
memperpendek lama rawat inap penderita tetapi tidak dapat berbeda bermakna secara
statistik.
Kata kunci: vitamin C, PPOK eksaserbasi akut, MDA plasma, lama rawat inap.
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Fadlia Yulistiana. 2016. Effect Of Vitamin C to the MDA plasma levels and Length
of Hospitalization of COPD patients with Acute Exacerbation. THESIS. Supervisor
I: Prof. Dr. Suradi, dr., Sp.P(K),MARS, II: Dr. Reviono, dr., Sp.P(K). Master Program
in Family Medicine, Post-Graduate Program, Sebelas Maret University Surakarta.
ABSTRACT
COPD is a lung disease characterized by the air flow limitation that is chronic,
progressive and not fully reversible due to inhalation of noxious gases or particles
resulting in chronic airway inflammation. Exacerbation and comorbid factors influence
the degree of severity disease. Increased airway inflammation and pulmonary
exacerbations lead to increased levels of plasma MDA, causing most patients need
treatment in hospitals. Vitamin C is an antioxidant vitamin that has anti-inflammatory
and antioxidant effects that can be added in COPD exacerbations
The research method using experimental clinical trials with pretest and post test design. The study aim was to determine the effect of vitamin C on MDA plasma
levels and length of hospitalization of patients with COPD exacerbations. Used 33
subjects acute exacerbation COPD patients were treated in hospitals Soehadi
Pridjonegoro Sragen in October-November 2015. Samples were taken by consecutive
sampling. Subjects were divided into two groups, the treatment group (n = 16 ) received
additional vitamin C therapy 1x1000 mg/ day and the control group (n = 17) treated
with an additional 5 mL of NaCl 0.9 % during the hospitalization. MDA plasma levels
were measured at entry and at discharge criteria are met. Length of stay is calculated
based on the number of days of care in hospitals.
There was no statistically significant difference (p = 0.43) towards decreased
levels of MDA plasma levels on vitamin C group (mean±SD= -0.86 ± 5.59 mol / L )
and control group (mean±SD= -2.81 ± 4.31). There was no tatistically significant
difference (p = 0.27) towards the length of hospitalization between vitamin C group
(mean±SD= 4.88 ± 2.13 days) and controls (mean±SD= 5.88 + 2.64 days).
Additional therapeutic vitamin C 1x1000 mg/ day in the acute exacerbation of
COPD standards treatment in this study can reduce levels of plasma MDA and
shortening the length of stay of the patients but there were no statistically significant
differences.
Key words: Vitamin C, acute exacerbation of COPD, MDA plasma levels, length of
hospitalization.
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