LAKSATIF Mekanisme Kerja Laktulosa Unchanged lactulose reaches colon Stimulate peristalsis Short colonic transit time Breakdown into short chain fatty acids (lactic acids, acetic acids etc) decrease in colonic pH Softening of faeces and increase in stool volume Increase in osmotic pressure & increase in biomass Relieve constipation (Pranami D et al, 2017) (Manhal Izzy,et al., 2016)
