11/15/2010
INFEKSI VIRUS PADA REPRODUCTIVE SYSTEM /
INFEKSI VIRUS MASA KEHAMILAN
HERPES SIMPLEX VIRUS (HSV)
Dr. Gerben F. Hutabarat DTM&H,Msc,SpMK.
Bgn : Mikrobilogi FK.USU
SIFAT VIRUS
I.
DNA VIRUS
1. HERPES SIMPLEX VIRUS (HSV)
2. CYTOMEGALO VIRUS (CMV)
3. HUMAN PAPILOMA VIRUS (HPV)
4. PARVO VIRUS (B19VIRUS) (B19V)
5. HEPATITIS B VIRUS (HBV)
II. RNA VIRUS
1. RUBI VIRUS (RUBELLA VIRUS)
2. HUMAN IMMUNODEFICIENCY VIRUS (HIV)
3. MEASLES VIRUS
4. MUMPS VIRUS
2. NEONATAL HERPES
CARA PENULARAN : NEONATALIN FECTION
GEJALA PENYAKIT : JOUNDICE, HEPATOSPLENO MEGALI,THOROM
BOCYTOPENIA, VESICULAR SKIN
DIAGNOSA LAB.
A. INOCULASI : VESICLE FLUID : TISSUE CULTURE(BHK4,HELC).
B. SEROLOGY.
: DNA, DOUBLE STRANDED, 100 nm
PENYAKIT
1. GENITAL HERPES
CARA PENULARAN : SEXUAL INTERCOURSE
GEJALA PENYAKIT : VESICULAR ERUPTION
DIAGNOSA LAB
: ISOLASI: VESICLE FLUID, SKIN SWAB
CYTOMEGALO VIRUS (CMV)
SIFAT VIRUS : DNA
PENYAKIT : CYTOMEGALIC INCLUSION DISEASE (CID)
CARA PENULARAN :
SEXUAL INTERCOUSE
BLOOD TRASFUSION
FETAL INFECTION
TRANSPLAN CENTALLY IN UTERO
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11/15/2010
GEJALA PENYAKIT PADA FETUS
DIAGNOSA LABORATORIUM
-
• ISOLASI : (URINE, THROAT SWAB)
• INOCULASI : HELC => CPE: SWALLEN CELL
• SEROLOGI : CFT,IF.
MENTAL RETARDATION
JOUNDICE
HEPATO-SPELENO MEGALI
BLOOD DISCRASI (TROMBO CYTOPENIA,HAEMOLITIC ANMIA)
MICROCEPHALI
MOTOR DISEASE
HUMAN PAPILOMA VIRUS (HPV)
SIFAT VIRUS : DNA DOUBLE STRANDED CIRCULAR (50 nm).
PENYAKIT
: GENITAL WARTZ (CONDYLOMA ACCUMINATA)
CARA PENULARAN : SEXUAL INTERCOUR SE
GEJALA PENYAKIT : MARKED FROLIFERATION OF EPITHELIAL
(CELL CONDYLOMA ACUMINATA)
DIAGNOSA LAB
: - KILOCYTES IN THE LESION
- SEROLOGY
PREVWNTION
: NO VACCIN AVIABLE
PARVO VIRUS B19
SIFAT VIRUS : DNA, SINGLE STRANDED
PENYAKIT :
1. SLAPPERT CHEEKS SYDROME
FIFTH DISEASE
APLASTIC ANEMIA
CARA PENULARAN :
RESPIRATION ROUTE ,BLOOD TRANSFUSIONS
DIAGNOSA LAB:
DITECTION : IgM , ISOLATION FROM THROAT SWAB, PCR DNA:
FOR BLOOD,AMNIOTIC FLUID
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11/15/2010
2. FETAL INFECTION
CARA PENULARAN : TRANS PLACENTAL
TRANS MISSION ( INFECTION FIRST TRISMESTER)
GEJALA : FETAL DEATH
DIAGNOSA LAB:
SEROLOGI : HI TEST, IgG RISING TITER.
IgM : (CFT, RIH)
PREVENTION :
VACCIN : ONE DOSE S.C (LIVE ATTENUATED) VIRUS VACCIN
RUBI VIRUS (RUBELLA VIRUS)
SIFAT VIRUS : RNA, 50-75 nm
PENYAKIT : RUBELLA (GERMAN MEASLES) IN PREGNAN CY),
INCUBATION PERIOD : 14-21 DAYS
CARA PENULARAN : -RESPIRATORY DROPLET
- TRANSPLASCENTALLY
GEJALA PENYAKIT : Pd.FETUS
- CONGENITAL DEFECT (TRIAD : CATARACT, NERVE DEFNES,
CACDIAC ABNORMALITY)
- RUBELLA SYNDROME
MEASLES VIRUS
SIFAT VIRUS:
RNA, 120-250 nm, ONE SEROLOGICAL TYPE.
PENYAKIT : MEASLES ( RUBEOLA = MORBILI)
INCUBATION PERIOD : 10-14 DAYS
CARA PENULARAN :
INHALATION RESPIRATION SECRETION
GEJALA PENYAKIT :
PADA IBU : FEVER, CONJUNTIVITIS, RUNNING NOSE, COUGHING,
KOPLIC SPOT IN BUCCAL
DIAGNOSA LAB:
-ISOLATION IN CELL CULTURE
-SEROLOGY : RISING TITER (GREATER THAN - 4 FOLD)
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PREVENTION
MEASLES VACCIN: ONE DOSE S.C (LIFE
ATTENUATED VACCINE).
FETUS.
-TRANS PLANCENTALLY
-FETAL DEATH
TERIMA KASIH
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K - 32 Infeksi Virus Selama Kehamilan (Mikrobiologi)